Interdepartmental Research Center
for the Innovation of Health Products

Services and competencies of the Operational Units

Each OU is coordinated by a responsible and is constituted by tenured and contract personnel. Tenured personnel is constituted by professors, associate professors, researchers, technicians, and administrative staff, devoting part of their time to BIOPHARMANET-TEC. Contract personnel is hired on demand, and it is mostly made of post doctoral fellows, research fellows and technicians.

Drug DiscoveryFood and Drug Department Viale delle Scienze 27/a 43124 ParmaSilvia Rivara 0521.905059–    EGFR inhibitors –    Endocannabinoid metabolism inhibitors and lipidic compounds related –    Compounds active on the melatoninergic metabolism –    Antibacterial compounds –    Compounds active on the CNS –    Carbohydrates synthesis and modifications –    Compounds anti-miR and anti-gene –    Chiarality and chiroptic methods –    Novel surfactants for the development of gene-delivery systems and gene therapy. –    Design and synthesis of bioactive molecules for the modulation of the gene expression. –    Synthesis of bioactive peptides and peptide carriers. –    Studies on the interaction molecules/biopolymers.
Drug Delivery e Process ChemistryFood and Drug Department Viale delle Scienze 27/a 43124 ParmaPatrizia Santi 0521.905069–    Administration of drugs through transdermal, oral and ocular way.  –    Preparation of solid and semisolid pharmaceutical forms and their evaluation with regard to mechanic properties, bio adhesion, release and biological tissues passage. –    Physic and chemical enhancement to improve drug transportation.   –    Pharmaceutical use of supercritical fluids. –    Chemistry of material for pharmaceutical use. –    Natural polymers for tissue engineering. –    Study of the mechanisms for the design and control of automated machines used in the pharmaceutical sector. –    Granular flow.
PharmacologyFood and Drug Department Viale delle Scienze 27/a 43124 ParmaFranco Bernini 0521.905039–    In vitro studies on the intracellular metabolism of cholesterol. –    Studies in in vivo experimental models for the evaluation of the reverse transportation of cholesterol. –    Ex vivo studies on the capability of animal serum to promote cholesterol efflux. –    In vitro, ex vivo and in vivo evaluation of the functional alteration due to mesenteric ischemic/reperfusion, stenosis and colitis.   –    Study of the gastric secretion in experimental models of gastro-duodenal ulcers induced by NSAIDs or ethanol.   –    In vitro and in vivo evaluation of the gastric secretion and markers for mucosal cytoprotection. –    In vivo study of analgesic and anti-inflammatory properties of natural and synthetic products, their mechanism of action involving the evaluation of the ratio between tolerated dose and lethal dose. –    Evaluation of the nutritional and protective effect after administration of complex aliments and their components. Study of the toxicological effects in vivo of food contaminants.    –    In vivo e ex vivo evaluation of pharmacological modulation of platelet aggregation by antithrombotic agents and definition of their tolerability.   –    Development of agents active on the Eph-ephrin system as potential chemotherapeutics.
Experimental medicine and surgeryDipartimento di Medicina Sperimentale Via Volturno 39 43125 ParmaRoberta Alfieri 0521.903768–    Proliferation assays and cellular viability. (MTT, flow cytometry, thymidine incorporation) –    Gene expression studies, signal transduction studies and protein analysis through Northern blotting, Western- blotting and RT- PCR –    Transportation and cellular metabolism measure through radioisotope use –    Studies of the mechanisms of cellular death and autophagy. –    Evaluation of single cell DNA damage (Halo assay). –    Gene cloning, transfection and gene silencing. –    Evaluation in murine model.
Biochemistry and molecular biologyDipartimento di Bioscienze Viale delle Scienze 23/a 43124 ParmaStefano Bettati 0521.905646–    Functional genomic (transcriptomic and phenotypic analysis) applied to the characterization of compounds of pharmacological and toxicological interest. –    Set up of assays based on gene engineering and DNA recombinant technology to identify xenoestrogen compounds (both agonist and antagonist) and to shape amyloid pathologies in Saccharomyces cerevisiae –    Production of detoxified recombinant proteins, such as engineered peptide immunogens endowed with self-adjuvant properties, to be used as vaccines. –    Proteomic and differential proteomic analysis of biological samples with and without drugs. –    Functional and spectroscopic characterization of proteins of pharmaceutical interest. –    Expression and purification of proteins of pharmaceutical interest. –    Modified hemoglobin as blood surrogate. –    Blood and plasma chemical and biochemical analysis. –     Design and validation of protein ligands through an integrated in silico/experimental approach. –     Enzyme immobilization in nanoporous silica gel for the development of biosensors and bioreactors. –     Cloning and expression of fluorescent proteins (green fluorescent protein and variants – GFPs), and fusion products between target proteins and GFPs, to be used in high resolution fluorescent microscopy.