Centro di Oncologia
Molecolare Traslazionale

Di seguito è riportata una lista non esaustiva delle pubblicazioni più significative svolte da ciascuna UP nell’ambito di attività del centro negli ultimi anni

Malpeli G, Filippini F, Tedone F, Torroni L, Alloggio M, Castelli C, Dal Cero M, Perris R, Tomezzoli A, De Manzoni G, Bencivenga M. Influence of Tumor Stroma on the Aggressiveness of Poorly Cohesive Gastric Carcinoma. J Pers Med. 2024 Feb 9;14(2):194. doi: 10.3390/jpm14020194. PMID: 38392627; PMCID: PMC10890005.

Mohammed S, Russo I, Ramazzina I. Uncovering the Role of Natural and Synthetic Small Molecules in Counteracting the Burden of α-Synuclein Aggregates and Related Toxicity in Different Models of Parkinson’s Disease. Int J Mol Sci. 2023 Aug 29;24(17):13370. doi: 10.3390/ijms241713370. PMID: 37686175; PMCID: PMC10488152.

Montalbano S, Bisceglie F, Pelosi G, Lazzaretti M, Buschini A. Modulation of Transcription Profile Induced by Antiproliferative Thiosemicarbazone Metal Complexes in U937 Cancer Cells. Pharmaceutics. 2023 Apr 24;15(5):1325. doi: 10.3390/pharmaceutics15051325. PMID: 37242567; PMCID: PMC10220753.

Montalbano S, Buschini A, Pelosi G, Bisceglie F. Antiproliferative Activity and DNA Interaction Studies of a Series of N4,N4-Dimethylated Thiosemicarbazone Derivatives. Molecules. 2023 Mar 20;28(6):2778. doi: 10.3390/molecules28062778. PMID: 36985750; PMCID: PMC10058200.

Montalbano S, Raboni S, Sidoli S, Mozzarelli A, Bettati S, Buschini A. Post- Translational Modifications of Histone Variants in the Absence and Presence of a Methionine-Depleting Enzyme in Normal and Cancer Cells. Cancers (Basel). 2023 Jan 15;15(2):527. doi: 10.3390/cancers15020527. PMID: 36672476; PMCID: PMC9857184.

Malpeli G, Barbi S, Innamorati G, Alloggio M, Filippini F, Decimo I,Castelli C, Perris R, Bencivenga M. Landscape of Druggable Molecular Pathways Downstream of Genomic CDH1/Cadherin-1 Alterations in Gastric Cancer. J Pers Med. 2022 Dec 3;12(12):2006. doi: 10.3390/jpm12122006. PMID: 36556227; PMCID: PMC9784514.

Marzouk B, Refifà M, Montalbano S, Buschini A, Negri S, Commisso M, Degola F. In Vitro Sprouted Plantlets of Citrullus colocynthis (L.) Schrad Shown to Possess Interesting Levels of Cucurbitacins and Other Bioactives against Pathogenic Fungi. Plants (Basel). 2022 Oct 14;11(20):2711. doi: 10.3390/plants11202711. PMID: 36297735; PMCID: PMC9611854.

Di Nunzio M, Loffi C, Montalbano S, Chiarello E, Dellafiora L, Picone G, Antonelli G, Tedeschi T, Buschini A, Capozzi F, Galaverna G, Bordoni A. Cleaning the Label of Cured Meat; Effect of the Replacement of Nitrates/Nitrites on Nutrients Bioaccessibility, Peptides Formation, and Cellular Toxicity of In Vitro Digested Salami. Int J Mol Sci. 2022 Oct 19;23(20):12555. doi: 10.3390/ijms232012555. PMID: 36293416; PMCID: PMC9604274.

Bisceglie F, Pelosi G, Orsoni N, Pioli M, Carcelli M, Pelagatti P, Pinelli S, Sadler PJ. Light Triggers the Antiproliferative Activity of Naphthalimide- Conjugated (η<sup>6</sup>-arene)ruthenium(II) Complexes. Int J Mol Sci. 2022 Jul 10;23(14):7624. doi: 10.3390/ijms23147624. PMID: 35886972; PMCID: PMC9322830.

Raboni S, Montalbano S, Stransky S, Garcia BA, Buschini A, Bettati S, Sidoli S, Mozzarelli A. A Key Silencing Histone Mark on Chromatin Is Lost When Colorectal Adenocarcinoma Cells Are Depleted of Methionine by Methionine γ-Lyase. Front Mol Biosci. 2021 Oct 1;8:735303. doi: 10.3389/fmolb.2021.735303. PMID: 34660696; PMCID: PMC8517235.

Ferrari E, Naponelli V, Bettuzzi S. Lemur Tyrosine Kinases and Prostate Cancer: A Literature Review. Int J Mol Sci. 2021 May 21;22(11):5453. doi: 10.3390/ijms22115453. PMID: 34064250; PMCID: PMC8196904.

Montalbano S, Degola F, Bartoli J, Bisceglie F, Buschini A, Carcelli M, Feretti D, Galati S, Marchi L, Orsoni N, Pelosi G, Pioli M, Restivo FM, Rogolino D, Scaccaglia M, Serra O, Spadola G, Viola GCV, Zerbini I, Zani C. The AFLATOX project: Approaching the Development of New Generation, Natural-Based Compounds for the Containment of the Mycotoxigenic Phytopathogen Aspergillus flavus and Aflatoxin Contamination. Int J Mol Sci. 2021 Apr 26;22(9):4520. doi: 10.3390/ijms22094520. PMID: 33926042; PMCID: PMC8123576.

Pioli M, Orsoni N, Scaccaglia M, Alinovi R, Pinelli S, Pelosi G, Bisceglie F. A New Photoactivatable Ruthenium(II) Complex with an Asymmetric Bis- Thiocarbohydrazone: Chemical and Biological Investigations. Molecules. 2021 Feb 10;26(4):939. doi: 10.3390/molecules26040939. PMID: 33578884; PMCID: PMC7916603.

Savi M, Bocchi L, Cacciani F, Vilella R, Buschini A, Perotti A, Galati S, Montalbano S, Pinelli S, Frati C, Corradini E, Quaini F, Ruotolo R, Stilli D, Zaniboni M. Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes. Part Fibre Toxicol. 2021 Jan 6;18(1):1. doi: 10.1186/s12989-020-00396-6. PMID: 33407654; PMCID: PMC7788732.

Lenzi C, Ramazzina I, Russo I, Filippini A, Bettuzzi S, Rizzi F. The Down- Regulation of Clusterin Expression Enhances the α Synuclein Aggregation Process. Int J Mol Sci. 2020 Sep 29;21(19):7181. doi: 10.3390/ijms21197181. PMID: 33003328; PMCID: PMC7582711.

Vilella R, Sgarbi G, Naponelli V, Savi M, Bocchi L, Liuzzi F, Righetti R, Quaini F, Frati C, Bettuzzi S, Solaini G, Stilli D, Rizzi F, Baracca A. Effects of Standardized Green Tea Extract and Its Main Component, EGCG, on Mitochondrial Function and Contractile Performance of Healthy Rat Cardiomyocytes. Nutrients. 2020 Sep 25;12(10):2949. doi: 10.3390/nu12102949. PMID: 32993022; PMCID: PMC7600665.

Izzo S, Naponelli V, Bettuzzi S. Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention. Nutrients. 2020 Apr 6;12(4):1010. doi: 10.3390/nu12041010. PMID: 32268584; PMCID: PMC7231128.

Pellegri V, Gorbi G, Buschini A. DNA damage detection by Comet Assay on Daphnia magna: Application in freshwater biomonitoring. Sci Total Environ. 2020 Feb 25;705:135780. doi: 10.1016/j.scitotenv.2019.135780. Epub 2019 Nov 27. PMID: 31972938.

Bonacini M, Negri A, Davalli P, Naponelli V, Ramazzina I, Lenzi C, Bettuzzi S, Rizzi F. Clusterin Silencing in Prostate Cancer Induces Matrix Metalloproteinases by an NFκB-Dependent Mechanism. J Oncol. 2019 Dec 6;2019:4081624. doi: 10.1155/2019/4081624. PMID: 31885575; PMCID: PMC6925831.

Galati S, Boni C, Gerra MC, Lazzaretti M, Buschini A. Autophagy: A Player in response to Oxidative Stress and DNA Damage. Oxid Med Cell Longev. 2019 Jul 29;2019:5692958. doi: 10.1155/2019/5692958. PMID: 31467633; PMCID: PMC6701339.

Malpeli G, Innamorati G, Decimo I, Bencivenga M, Nwabo Kamdje AH, Perris R, Bassi C. Methylation Dynamics of RASSF1A and Its Impact on Cancer. Cancers (Basel). 2019 Jul 9;11(7):959. doi: 10.3390/cancers11070959. PMID: 31323949; PMCID: PMC6678546.

Paredi G, Mori F, de Marino MG, Raboni S, Marchi L, Galati S, Buschini A, Lo Fiego DP, Mozzarelli A. Is the protein profile of pig Longissimus dorsi affected by gender and diet? J Proteomics. 2019 Aug 30;206:103437. doi: 10.1016/j.jprot.2019.103437. Epub 2019 Jul 2. PMID: 31271901.

Negri A, Naponelli V, Rizzi F, Bettuzzi S. Molecular Targets of Epigallocatechin-Gallate (EGCG): A Special Focus on Signal Transduction and Cancer. Nutrients. 2018 Dec 6;10(12):1936. doi: 10.3390/nu10121936. PMID: 30563268; PMCID: PMC6315581.

Tamburini E, Dallatomasina A, Quartararo J, Cortelazzi B, Mangieri D, Lazzaretti M, Perris R. Structural deciphering of the NG2/CSPG4 proteoglycan multifunctionality. FASEB J. 2019 Mar;33(3):3112-3128. doi: 10.1096/fj.201801670R. Epub 2018 Dec 14. PMID: 30550356.

Errede M, Mangieri D, Longo G, Girolamo F, de Trizio I, Vimercati A, Serio G, Frei K, Perris R, Virgintino D. Tunneling nanotubes evoke pericyte/endothelial communication during normal and tumoral angiogenesis. Fluids Barriers CNS. 2018 Oct 5;15(1):28. doi: 10.1186/s12987-018-0114-5. PMID: 30290761; PMCID: PMC6173884.

Bocchi L, Savi M, Naponelli V, Vilella R, Sgarbi G, Baracca A, Solaini G, Bettuzzi S, Rizzi F, Stilli D. Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production. Cell Physiol Biochem. 2018;47(3):1230-1243. doi: 10.1159/000490219. Epub 2018 Jun 15. PMID: 29913456.

Pollino S, Benassi MS, Pazzaglia L, Conti A, Bertani N, Righi A, Piccinni- Leopardi M, Picci P, Perris R. Prognostic role of XTP1/DEPDC1B and SDP35/DEPDC1A in high grade soft-tissue sarcomas. Histol Histopathol. 2018 Jun;33(6):597-608. doi: 10.14670/HH-11-959. Epub 2018 Jan 3. PMID: 29297565.

Naponelli V, Ramazzina I, Lenzi C, Bettuzzi S, Rizzi F. Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges. Antioxidants (Basel). 2017 Apr 5;6(2):26. doi: 10.3390/antiox6020026. PMID: 28379200; PMCID: PMC5488006.

Bozzetti C, Quaini F, Squadrilli A, Tiseo M, Frati C, Lagrasta C, Azzoni C, Bottarelli L, Galetti M, Alama A, Belletti S, Gatti R, Passaro A, Gradilone A, Cavazzoni A, Alfieri R, Petronini PG, Bonelli M, Falco A, Carubbi C, Pedrazzi G, Nizzoli R, Naldi N, Pinto C, Ardizzoni A. Isolation and Characterization of Circulating Tumor Cells in Squamous Cell Carcinoma of the Lung Using a Non- EpCAM-Based Capture Method. PLoS One. 2015 Nov 16;10(11):e0142891. doi: 10.1371/journal.pone.0142891. PMID: 26571236; PMCID: PMC4646671.

Modernelli A, Naponelli V, Giovanna Troglio M, Bonacini M, Ramazzina I, Bettuzzi S, Rizzi F. EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism. Sci Rep. 2015 Oct 16;5:15270. doi: 10.1038/srep15270. PMID: 26471237; PMCID: PMC4607952.

Di Marcantonio D, Galli D, Carubbi C, Gobbi G, Queirolo V, Martini S, Merighi S, Vaccarezza M, Maffulli N, Sykes SM, Vitale M, Mirandola P. PKCε as a novel promoter of skeletal muscle differentiation and regeneration. Exp Cell Res. 2015 Nov 15;339(1):10-9. doi: 10.1016/j.yexcr.2015.09.017. Epub 2015 Sep 30. PMID: 26431586; PMCID: PMC5130411.

Alias C, Rocchi L, Ribatti D, Caraffi S, D’Angelo A, Perris R, Mangieri D. MMPs and angiogenesis affect the metastatic potential of a human vulvar leiomyosarcoma cell line. J Cell Mol Med. 2015 Sep;19(9):2098-107. doi: 10.1111/jcmm.12565. Epub 2015 May 22. PMID: 26010680; PMCID: PMC4568914.

Farnedi A, Rossi S, Bertani N, Gulli M, Silini EM, Mucignat MT, Poli T, Sesenna E, Lanfranco D, Montebugnoli L, Leonardi E, Marchetti C, Cocchi R, Ambrosini-Spaltro A, Foschini MP, Perris R. Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors. BMC Cancer. 2015 May 3;15:352. doi: 10.1186/s12885-015-1336-4. PMID: 25935541; PMCID: PMC4429505.

Naponelli V, Modernelli A, Bettuzzi S, Rizzi F. Roles of autophagy induced by natural compounds in prostate cancer. Biomed Res Int. 2015;2015:121826. doi: 10.1155/2015/121826. Epub 2015 Mar 3. PMID: 25821782; PMCID: PMC4364006.

Nicolosi PA, Dallatomasina A, Perris R. Theranostic impact of NG2/CSPG4 proteoglycan in cancer. Theranostics. 2015 Feb 15;5(5):530-44. doi: 10.7150/thno.10824. PMID: 25767619; PMCID: PMC4350014.

Spinillo A, Cesari S, Bariselli S, Tzialla C, Gardella B, Silini EM. Placental lesions associated with oligohydramnios in fetal growth restricted (FGR) pregnancies. Placenta. 2015 May;36(5):538-44. doi: 10.1016/j.placenta.2015.02.007. Epub 2015 Feb 23. PMID: 25735841.

Negri FV, Dal Bello B, Porta C, Campanini N, Rossi S, Tinelli C, Poggi G, Missale G, Fanello S, Salvagni S, Ardizzoni A, Maria SE. Expression of pERK and VEGFR-2 in advanced hepatocellular carcinoma and resistance to sorafenib treatment. Liver Int. 2015 Aug;35(8):2001-8. doi: 10.1111/liv.12778. Epub 2015 Jan 22. PMID: 25559745.

Alberizzi P, Spinillo A, Gardella B, Cesari S, Silini EM. Evaluation of the HPV typing INNO-LiPA EXTRA assay on formalin-fixed paraffin-embedded cervical biopsy samples. J Clin Virol. 2014 Dec;61(4):535-9. doi: 10.1016/j.jcv.2014.10.016. Epub 2014 Nov 4. PMID: 25464970.

Bonacini M, Coletta M, Ramazzina I, Naponelli V, Modernelli A, Davalli P, Bettuzzi S, Rizzi F. Distinct promoters, subjected to epigenetic regulation, drive the expression of two clusterin mRNAs in prostate cancer cells. Biochim Biophys Acta. 2015 Jan;1849(1):44-54. doi: 10.1016/j.bbagrm.2014.11.003. Epub 2014 Nov 8. PMID: 25464035.

Chiu M, Tardito S, Pillozzi S, Arcangeli A, Armento A, Uggeri J, Missale G, Bianchi MG, Barilli A, Dall’Asta V, Campanini N, Silini EM, Fuchs J, Armeanu- Ebinger S, Bussolati O. Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. Br J Cancer. 2014 Sep 9;111(6):1159-67. doi: 10.1038/bjc.2014.425. Epub 2014 Jul 29. PMID: 25072259; PMCID: PMC4453854.

Caraffi S, Corradi D, Campanini N, Govoni P, Rocchi L, Perris R, Mangieri D. Microcirculation density and maturity in uterine and soft tissue leiomyosarcomas: an immunohistochemical study. Histol Histopathol. 2015 Jan;30(1):69-76. doi: 10.14670/HH-30.69. Epub 2014 Jul 21. PMID: 25046102.

Spinillo A, Gardella B, Chiesa A, Cesari S, Alberizzi P, Silini EM. Diagnostic accuracy of colposcopy in relation to human papillomavirus genotypes and multiple infection. Gynecol Oncol. 2014 Sep;134(3):527-33. doi: 10.1016/j.ygyno.2014.07.006. Epub 2014 Jul 12. PMID: 25026638.

Girolamo F, Dallatomasina A, Rizzi M, Errede M, Wälchli T, Mucignat MT, Frei K, Roncali L, Perris R, Virgintino D. Diversified expression of NG2/CSPG4 isoforms in glioblastoma and human foetal brain identifies pericyte subsets. PLoS One. 2013 Dec 26;8(12):e84883. doi: 10.1371/journal.pone.0084883. Erratum in: PLoS One. 2014;9(4):e95120. PMID: 24386429; PMCID: PMC3873429.

Azzoni C, Bottarelli L, Cecchini S, Ziccarelli A, Campanini N, Bordi C, Sarli L, Silini EM. Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: associations with clinicopathological and molecular features. Pathol Res Pract. 2014 Feb;210(2):111-7. doi: 10.1016/j.prp.2013.11.004. Epub 2013 Nov 22. PMID: 24332575.

Bottarelli L, Azzoni C, Pizzi S, D’Adda T, Silini EM, Bordi C, Rindi G. Adenomatous polyposis coli gene involvement in ileal enterochromaffin cell neuroendocrine neoplasms. Hum Pathol. 2013 Dec;44(12):2736-42. doi:10.1016/j.humpath.2013.06.019. Epub 2013 Oct 16. PMID: 24139208.

Garusi E, Rossi S, Perris R. Antithetic roles of proteoglycans in cancer. Cell Mol Life Sci. 2012 Feb;69(4):553-79. doi: 10.1007/s00018-011-0816-1. Epub 2011 Oct 2. PMID: 21964924; PMCID: PMC11114698.

 .