<\/p>\n\n\n\n
Each OU is coordinated by a responsible and is constituted by tenured and contract personnel. Tenured personnel is constituted by professors, associate professors, researchers, technicians, and administrative staff, devoting part of their time to BIOPHARMANET-TEC. Contract personnel is hired on demand, and it is mostly made of post doctoral fellows, research fellows and technicians.<\/p>\n\n\n\n Each OU is coordinated by a responsible and is constituted by tenured and contract personnel. Tenured personnel is constituted by […]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":562,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/pages\/583"}],"collection":[{"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/comments?post=583"}],"version-history":[{"count":1,"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/pages\/583\/revisions"}],"predecessor-version":[{"id":785,"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/pages\/583\/revisions\/785"}],"up":[{"embeddable":true,"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/pages\/562"}],"wp:attachment":[{"href":"https:\/\/www.centritecnopolo.unipr.it\/biopharmanet-tec\/wp-json\/wp\/v2\/media?parent=583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}OPERATIONAL UNIT<\/strong><\/td> SITE<\/strong><\/td> RESPONSIBLE<\/strong><\/td> COMPETENCES AND RESEARCH ACTIVITIES<\/strong><\/td><\/tr> Drug Discovery<\/td> Food and Drug Department Viale delle Scienze 27\/a 43124 Parma<\/td> Silvia Rivara silvia.rivara@unipr.it<\/a> 0521.905059<\/td> \u2013 EGFR inhibitors \u2013 Endocannabinoid metabolism inhibitors and lipidic compounds related \u2013 Compounds active on the melatoninergic metabolism \u2013 Antibacterial compounds \u2013 Compounds active on the CNS \u2013 Carbohydrates synthesis and modifications \u2013 Compounds anti-miR and anti-gene \u2013 Chiarality and chiroptic methods \u2013 Novel surfactants for the development of gene-delivery systems and gene therapy. \u2013 Design and synthesis of bioactive molecules for the modulation of the gene expression. \u2013 Synthesis of bioactive peptides and peptide carriers. \u2013 Studies on the interaction molecules\/biopolymers.<\/td><\/tr> Drug Delivery e Process Chemistry<\/td> Food and Drug Department Viale delle Scienze 27\/a 43124 Parma<\/td> Patrizia Santi patrizia.santi@unipr.it<\/a> 0521.905069<\/td> \u2013 Administration of drugs through transdermal, oral and ocular way. \u2013 Preparation of solid and semisolid pharmaceutical forms and their evaluation with regard to mechanic properties, bio adhesion, release and biological tissues passage. \u2013 Physic and chemical enhancement to improve drug transportation. \u2013 Pharmaceutical use of supercritical fluids. \u2013 Chemistry of material for pharmaceutical use. \u2013 Natural polymers for tissue engineering. \u2013 Study of the mechanisms for the design and control of automated machines used in the pharmaceutical sector. \u2013 Granular flow.<\/td><\/tr> Pharmacology<\/td> Food and Drug Department Viale delle Scienze 27\/a 43124 Parma<\/td> Franco Bernini f.bernini@unipr.it<\/a> 0521.905039<\/td> \u2013 In vitro studies on the intracellular metabolism of cholesterol. \u2013 Studies in in vivo experimental models for the evaluation of the reverse transportation of cholesterol. \u2013 Ex vivo studies on the capability of animal serum to promote cholesterol efflux. \u2013 In vitro, ex vivo and in vivo evaluation of the functional alteration due to mesenteric ischemic\/reperfusion, stenosis and colitis. \u2013 Study of the gastric secretion in experimental models of gastro-duodenal ulcers induced by NSAIDs or ethanol. \u2013 In vitro and in vivo evaluation of the gastric secretion and markers for mucosal cytoprotection. \u2013 In vivo study of analgesic and anti-inflammatory properties of natural and synthetic products, their mechanism of action involving the evaluation of the ratio between tolerated dose and lethal dose. \u2013 Evaluation of the nutritional and protective effect after administration of complex aliments and their components. Study of the toxicological effects in vivo of food contaminants. \u2013 In vivo e ex vivo evaluation of pharmacological modulation of platelet aggregation by antithrombotic agents and definition of their tolerability. \u2013 Development of agents active on the Eph-ephrin system as potential chemotherapeutics.<\/td><\/tr> Experimental medicine and surgery<\/td> Dipartimento di Medicina Sperimentale Via Volturno 39 43125 Parma<\/td> Roberta Alfieri roberta.alfieri@unipr.it<\/a> 0521.903768<\/td> \u2013 Proliferation assays and cellular viability. (MTT, flow cytometry, thymidine incorporation) \u2013 Gene expression studies, signal transduction studies and protein analysis through Northern blotting, Western- blotting and RT- PCR \u2013 Transportation and cellular metabolism measure through radioisotope use \u2013 Studies of the mechanisms of cellular death and autophagy. \u2013 Evaluation of single cell DNA damage (Halo assay). \u2013 Gene cloning, transfection and gene silencing. \u2013 Evaluation in murine model.<\/td><\/tr> Biochemistry and molecular biology<\/td> Dipartimento di Bioscienze Viale delle Scienze 23\/a 43124 Parma<\/td> Stefano Bettati Stefano.bettati@unipr.it<\/a> 0521.905646<\/td> \u2013 Functional genomic (transcriptomic and phenotypic analysis) applied to the characterization of compounds of pharmacological and toxicological interest. \u2013 Set up of assays based on gene engineering and DNA recombinant technology to identify xenoestrogen compounds (both agonist and antagonist) and to shape amyloid pathologies in Saccharomyces cerevisiae \u2013 Production of detoxified recombinant proteins, such as engineered peptide immunogens endowed with self-adjuvant properties, to be used as vaccines. \u2013 Proteomic and differential proteomic analysis of biological samples with and without drugs. \u2013 Functional and spectroscopic characterization of proteins of pharmaceutical interest. \u2013 Expression and purification of proteins of pharmaceutical interest. \u2013 Modified hemoglobin as blood surrogate. \u2013 Blood and plasma chemical and biochemical analysis. \u2013 Design and validation of protein ligands through an integrated in silico\/experimental approach. \u2013 Enzyme immobilization in nanoporous silica gel for the development of biosensors and bioreactors. \u2013 Cloning and expression of fluorescent proteins (green fluorescent protein and variants \u2013 GFPs), and fusion products between target proteins and GFPs, to be used in high resolution fluorescent microscopy.<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"