Di seguito è riportata una lista non esaustiva delle pubblicazioni più significative svolte da ciascuna UO nell’ambito di attività del centro dal 2015 ad oggi
UO DRUG DISCOVERY
2016
Pala, Daniele; Rivara Silvia; Mor Marco; et al Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase. GLYCOBIOLOGY Volume: 26 Issue: 6 Pages: 640-654
Scalvini, Laura; Vacondio, Federica; Bassi, Michele; et al Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. SCIENTIFIC REPORT Volume: 6 Article number: 31036
Castelli, Riccardo; Giacomini, Arianna; Anselmi, Mattia; et al Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors. JOURNAL OF MEDICINAL CHEMISTRY Volume: 59 Pages: 4651-4663
Salvio, Riccardo; Volpi, Stefano; Cacciapaglia, Roberta et al. Upper Rim Bifunctional cone-Calix[4]arenes Based on a Ligated Metal Ion and a Guanidinium Unit as DNAase and RNAase Mimics. JOURNAL OF ORGANIC CHEMISTRY, Volume: 81 Issue: 11, Pages 4728–4735.
Baldini, Laura; Casnati, Alessandro; Sansone, Francesco. Biomacromolecule Recognition by Calixarene Macrocycles, In Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering; Wilson Andrew Ed., Waltham, MA: Elsevier.
2015
Campanini, Barbara; Pieroni, Marco; Raboni, Samanta; et al Inhibitors of the Sulfur Assimilation Pathway in Bacterial Pathogens as Enhancers of Antibiotic Therapy. CURRENT MEDICINAL CHEMISTRY Volume: 22 Issue: 2 Pages: 187-213
Capoferri, Luigi; Lodola, Alessio; Rivara, Silvia; et al. Quantum Mechanics/Molecular Mechanics Modeling of Covalent Addition between EGFR-Cysteine 797 and N-(4-Anilinoquinazolin-6-yl) Acrylamide. JOURNAL OF CHEMICAL INFORMATION AND MODELING Volume: 55 Issue: 3 Pages: 589-599
Scaravaggi, Stefano; Macerata, Elena; Galletta, Michele; et al. Hydrophilic 1,10-phenanthroline derivatives for selective Am(III) stripping into aqueous solutionsJOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY Volume: 303 Issue: 3 Pages: 1811-1820
Pieroni, Marco; Annunziato, Giannamaria; Azzali, Elisa; et al.Further insights into the SAR of alpha-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Volume: 92 Pages: 377-386
Gallego-Yerga, Laura; Lomazzi, Michela; Franceschi, Valentina; et al. Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study.ORGANIC & BIOMOLECULAR CHEMISTRY Volume: 13 Issue: 6 Pages: 1708-1723
Dotsey, Emmanuel Y; Jung, Kwang-Mook; Basit, Abdul; et al. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chemistry & biology Volume: 22 Issue: 5 Pages: 619-28
Curti, Claudio; Sartori, Andrea; Battistini, Lucia; et al. Pushing the Boundaries of Vinylogous Reactivity: Catalytic Enantioselective Mukaiyama Aldol Reactions of Highly Unsaturated 2-Silyloxyindoles. CHEMISTRY-A EUROPEAN JOURNAL Volume: 21 Issue: 17 Pages: 6433-6442
UO DRUG DELIVERY E TECNOLOGIE DI PROCESSO
2016
Benetti, Camillo, Flammini L, Vivo Valentina, et al. Esomeprazole immediate release tablets: Gastric mucosa ex vivo permeation, absorption and antisecretory activity in conscious rats. JOURNAL OF CONTROLLED RELEASE. Volume: 239 Pages :203-210.
Buttini, Francesca; Pasquali, Irene; Brambilla, Gaetano; et al. Multivariate Analysis of Effects of Asthmatic Patient Respiratory Profiles on the In Vitro Performance of a Reservoir Multidose and a Capsule-Based Dry Powder Inhaler. PHARMACEUTICAL RESEARCH Volume: 33 Issue: 3 Pages: 701-715.
Buttini, Francesca; Brambilla, Gaetano; Copelli D; et al. Effect of Flow Rate on In Vitro Aerodynamic Performance of NEXThaler(®) in Comparison with Diskus(®) and Turbohaler(®) Dry Powder Inhalers. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY Volume: 29 Issue: 2 Pages:167-178.
Colombo, Gaia; Bortolotti, Fabrizio; Chiapponi, Veronica; et al. Nasal powders of thalidomide for local treatment of nose bleeding in persons affected by hereditary hemorrhagic telangiectasia. INTERNATIONAL JOURNAL OF PHARMACEUTICS Volume: 514 Issue: 1 Pages: 229-237
Della Bella, Andrea; Müller, Michele; Soldati, Luca; et al. Quantitative determination of micronization-induced changes in the solid state of lactose. INTERNATIONAL JOURNAL OF PHARMACEUTICS Volume: 505 Issue: 1-2 Pages: 383-393.
Elviri, Lisa; Bergonzi, Carlo; Bianchera, Annalisa; Bettini, Ruggero. Mapping insulin non-covalent interactions with natural polysaccharides by hydrogen/deuterium exchange mass spectrometry. RAPID COMMUNICATIONS MASS SPECTROMETRY Volume: 30 Issue: 21 Pages: 2323-2330.
Elviri, Lisa; Foresti, Ruben; Bianchera, Annalisa; et al. 3D-printed polylactic acid supports for enhanced ionization efficiency in desorption electrospray mass spectrometry analysis of liquid and gel samples. TALANTA Volume 155 Pages: 321-328.
Galli, Carlo; Parisi Ludovica, Elviri Lisa; et al. Chitosan scaffold modified with D-(+) raffinose and enriched with thiol-modified gelatin for improved osteoblast adhesion. BIOMEDICAL MATERIALS Volume: 11 Issue; 1 Article :015004.
Buttini, Francesca; Pasquali, Irene; Brambilla, Gaetano; et al. Multivariate Analysis of Effects of Asthmatic Patient Respiratory Profiles on the In Vitro Performance of a Reservoir Multidose and a Capsule-Based Dry Powder Inhaler. PHARMACEUTICAL RESEARCH Volume: 33 Issue: 3 Pages: 701-715.
Buttini, Francesca; Brambilla, Gaetano; Copelli D; et al. Effect of Flow Rate on In Vitro Aerodynamic Performance of NEXThaler(®) in Comparison with Diskus(®) and Turbohaler(®) Dry Powder Inhalers. JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY Volume: 29 Issue: 2 Pages:167-178.
2015
Bacchi, Alessia; Bourne, Susan; Cantoni, Giulia; et al. Reversible Guest Removal and Selective Guest Exchange with a Covalent Dinuclear Wheel-and-Axle Metallorganic Host Constituted by Half-Sandwich Ru(II) Wheels Connected by a Linear Diphosphine Axle. CRYSTAL GROWTH & DESIGN Volume: 15 Issue: 4 Pages: 1876-1888
Bacchi, Alessia; Loffi, Cecilia; Pagano, Paolo; et al. Solid-state and solution characterization of half-sandwich Ru(II) complexes with carboxylic ligands containing N-based coordinating functions.JOURNAL OF ORGANOMETALLIC CHEMISTRY Volume: 778 Pages: 1-9
Belotti, Silvia; Rossi, Alessandra; Colombo, Paolo; et al.Spray-dried amikacin sulphate powder for inhalation in cystic fibrosis patients: The role of ethanol in particle formation.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Volume: 93 Pages: 165-72.
Comfort, Claurice; Garrastazu, Gabriela; Pozzoli, Michele; et al. Opportunities and Challenges for the Nasal Administration of Nanoemulsions. CURRENT TOPICS IN MEDICINAL CHEMISTRY Volume: 15 Issue: 4 Pages: 356-368
De Robertis, Simona; Bonferoni, Maria Cristina; Elviri, Lisa; et al. Advances in oral controlled drug delivery: the role of drug-polymer and interpolymer non-covalent interactions. EXPERT OPINION ON DRUG DELIVERY Volume: 12 Issue: 3 Pages: 441-453.
Martinelli, Francesco; Balducci, Anna Giulia; Rossi, Alessandra; et al “Pierce and inhale” design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs INTERNATIONAL JOURNAL OF PHARMACEUTICS Volume: 487 Issue: 1-2 Pages: 197-204
Pescina, Silvia; Govoni, Paolo; Potenza, Arianna; et al. Development of a Convenient ex vivo Model for the Study of the Transcorneal Permeation of Drugs: Histological and Permeability Evaluation. JOURNAL OF PHARMACEUTICAL SCIENCES Volume: 104 Issue: 1 Pages: 63-71.
Pescina, Silvia; Sonvico, Fabio; Santi, Patrizia; et al Therapeutics and Carriers: The Dual Role of Proteins in Nanoparticles for Ocular Delivery. CURRENT TOPICS IN MEDICINAL CHEMISTRY Volume: 15 Issue: 4 Pages: 369-385.
Raphael, Anthony P; Garrastazu, Gabriela; Sonvico, Fabio; et al. Formulation design for topical drug and nanoparticle treatment of skin disease. Therapeutic delivery Volume: 6 Issue: 2 Pages: 197-216
Rotoli, Bianca M.; Gatti, Rita; Movia, Dania; et al. Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay. NANOTOXICOLOGY Volume: 9 Issue: 2 Pages: 230-241
Sonvico, Fabio; Coleman, Victoria; Traini, Daniela; et al. Evolved gas analysis during thermal degradation of salbutamol sulphate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY Volume: 120 Issue: 1 Pages: 789-794
UO FARMACOLOGIA
2015
Ronda, Nicoletta; Greco, Daniela; Adorni, Maria Pia; et al. Newly Identified Antiatherosclerotic Activity of Methotrexate and Adalimumab Complementary Effects on Lipoprotein Function and Macrophage Cholesterol Metabolism. ARTHRITIS & RHEUMATOLOGY Volume: 67 Issue: 5 Pages: 1155-1164
Calabresi, Laura; Gomaraschi, Monica; Simonelli, Sara; et al. Insights from inherited HDL disorders. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS Volume: 1851 Issue: 1 Special Issue: SI Pages: 13-18
UO MEDICINA E CHIRURGIA SPERIMENTALE
2016
La Monica Sivia., Madeddu Denise., Tiseo Marcello., et al.Vivo V., (2016) Combination of gefitinib and pemetrexed prevents the acquisition of TKI resistance in NSCLC cell lines carrying EGFR-activating mutations. JOURNAL OF THORACIC ONCOLOGY. 11(7):1051-1063.
Bonelli Mara., Fumarola Claudia., La Monica Silvia., Alfieri Roberta. (2016) New therapeutic strategies for malignant pleural mesothelioma. BIOCHEMICAL PHARMACOLOGY. In press
Leuzzi G, Rocco G, Ruffini E, et al. Multimodality therapy for locally advanced thymomas: A propensity score-matched cohort study from the European Society of Thoracic Surgeons Database.
J THORAC CARDIOVASC SURG. 2016 Jan;151(1):47-57.
Fiorelli A, Caronia FP, Daddi N et al. Sublobar resection versus lobectomy for stage I non-small cell lung cancer: an appropriate choice in elderly patients?SURG TODAY. 2016 Dec;46(12):1370-1382.
Ventura L, Gnetti L, Silini EM, et al.Placental Transmogrification of the Lung Presenting as a Giant Bulla Associated With a Pulmonary Hamartoma. ANN THORAC SURG. 2016 Jul;102(1):e61.
Ampollini L, Ventura L, Carbognani P.Postoperative Subconjunctival Emphysema. OPHTHALMOLOGY. 2016 Jun;123(6):1180
2015
Bozzetti Cecilia ., Quaini Federco., Squadrilli Anna., et al. (2015) Isolation and characterization of circulating tumor cells in squamous cell carcinoma of the lung using a non-EpCAM-based capture method. PLOS One. 10(11): e0142891
Galetti Maricla., Petronini Pier Giorgio, Fumarola Claudia, et al. (2015) Effect of ABCG2/BCRP expression on efflux amd uptake of gefitinib in NSCLC cell lines. PLOS One. 10(11): e0141795
Bonelli Mara, Cavazzoni Andrea, Saccani Francesca., et.al. (2015) Inhibition of PI3K pathway reduces invasiveness and epithelial-to-mesenchymal transition in squamous lung cancer cell lines harboring PIK3CA gene alterations. MOLECULAR CANCER THERAP. 14: 1916-1927.
Romeo, Agostino; Tarabella, Giuseppe; D’Angelo, Pasquale; et al. Drug-induced cellular death dynamics monitored by a highly sensitive organic electrochemical system. BIOSENSORS & BIOELECTRONICS Volume: 68 Pages: 791-797
Tiseo M, Gelsomino F, Alfieri RR., et al. FGFR as potential target in the treatment of squamous non small cell lung cancer. CANCER TREATMENT REVIEWS Volume: 41 Issue: 6 Pages: 527-39
Galvani E., Sun J., Leon L.G., et.al (2015) NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor. ONCOTARGET 6: 42717-42732.
Rossini M, Ruffini L, Ampollini L . et al. Synchronous thyroid metastasis from lung adenocarcinoma.
ANN ITAL CHIR. 2015;86:560-2.
Silva M, Bankier AA, Centra F, et al. Longitudinal evolution of incidentally detected solitary pure ground-glass nodules on CT: relation to clinical metrics. DIAGN INTERV RADIOL. 2015 Sep-Oct;21(5):385-90.
Lorusso B, Falco A, Madeddu D, et al. Isolation and Characterization of Human Lung Lymphatic Endothelial Cells. BIOMED RES INT. 2015;2015:747864.
Corradi M, Poli D, Banda I et al. Exhaled breath analysis in suspected cases of non-small-cell lung cancer: a cross-sectional study. J BREATH RES. 2015 Jan 29;9(2):027101.
UO BIOCHIMICA E BIOLOGIA MOLECOLARE
2015
Fruscalzo A, Londero Ap, Driul L, Henze A, Tonutti L, Ceraudo M, Zanotti G, Berni R, Schweigert Fj, Raila J. First trimester concentrations of the TTR-RBP4-retinol complex components as early markers of insulin-treated gestational diabetes mellitus. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Volume: 53 Issue: 10 Pages:1643-51
Cianci M, Folli C, Zonta F, Florio P, Berni R, Zanotti G. Structural evidence for asymmetric ligand binding to transthyretin. ACTA D, BIOLOGICAL CRYSTRALLOGRAPHY. Volume: 71 Issue: Pt 8 Pages:1582-92
Campanini, Barbara; Pieroni, Marco; Raboni, Samanta; et al. Inhibitors of the Sulfur Assimilation Pathway in Bacterial Pathogens as Enhancers of Antibiotic Therapy. CURRENT MEDICINAL CHEMISTRY Volume: 22 Issue: 2 Pages: 187-213.
Conti, Anastasia; Carnevali, Davide; Bollati, Valentina; et al. Identification of RNA polymerase III-transcribed Alu loci by computational screening of RNA-Seq data. NUCLEIC ACIDS RESEARCH Volume: 43 Issue: 2 Pages: 817-835
Fraccia, Tommaso P.; Smith, Gregory P.; Zanchetta, Giuliano; et al. Abiotic ligation of DNA oligomers templated by their liquid crystal ordering. NATURE COMMUNICATIONS Volume: 6 Article Number: 6424.
Gallego-Yerga, Laura; Lomazzi, Michela; Franceschi, Valentina; et al. Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study. ORGANIC & BIOMOLECULAR CHEMISTRY Volume: 13 Issue: 6 Pages: 1708-1723.
Marchetti, Marialaura; Bruno, Stefano; Campanini, Barbara; et al. Regulation of human serine racemase activity and dynamics by halides, ATP and malonate. AMINO ACIDS Volume: 47 Issue: 1 Pages: 163-173.
